Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 6/20 | 0.60 |
| ▸ | PRKACG | P22612 | 5/20 | 0.60 |
| ▸ | PRKACB | P22694 | 5/20 | 0.60 |
| ▸ | AKT2 | P31751 | 3/20 | 0.60 |
| ▸ | PRKCG | P05129 | 5/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.56 |
| ▸ | PRKCB | P05771 | 4/20 | 0.56 |
| ▸ | PRKCA | P17252 | 4/20 | 0.56 |
| ▸ | PRKCH | P24723 | 4/20 | 0.56 |
| ▸ | PRKCI | P41743 | 4/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543805 | 0.91 | PRKACA (0.60) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9542718 | 0.82 | PRKCG (0.64) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9483657 | 0.79 | FLT3 (0.59) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9483651 | 0.79 | FLT3 (0.59) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9542795 | 0.79 | PRKCG (0.68) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL7316260 | 0.78 | FLT3 (0.51) | PRKACAPRKACGPRKACBPRKCGPRKCZ | |
| SCHEMBL9541290 | 0.78 | PRKCG (0.86) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9484619 | 0.77 | FLT3 (0.57) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL2456459 | 0.77 | FLT3 (0.56) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL2456469 | 0.77 | FLT3 (0.56) | PRKACAPRKACGPRKACBAKT2PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013072-A1 | 5-ISOQUINOLINESULFONAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITING AGENTS | ITALFARMACO S.P.A. (IT) | 1993-07-08 | — | — | WO | disclosed |