Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677674 | 0.79 | NOTUM (0.60) | NOTUMBRD4CES1CYP2D6CYP2C9 | |
| SCHEMBL9545463 | 0.79 | NOTUM (0.44) | NOTUMBRD4CES1CYP2D6CYP2C9 | |
| SCHEMBL12043687 | 0.72 | NOTUM (0.55) | NOTUMCES1CYP2D6CYP2C9TRPA1 | |
| SCHEMBL8578821 | 0.69 | CES1 (0.42) | CES1NPC1RAB9AKDM4EALOX15 | |
| SCHEMBL30003296 | 0.69 | NOTUM (1.00) | NOTUMCES1CYP2D6CYP2C9RAB9A | |
| SCHEMBL1048074 | 0.69 | NOTUM (1.00) | NOTUMCES1CYP2D6CYP2C9RAB9A | |
| SCHEMBL4364295 | 0.67 | BRD4 (0.55) | NOTUMBRD4CYP2D6CYP2C9POLB | |
| SCHEMBL5636228 | 0.66 | KDM4E (0.64) | NPC1RAB9AKDM4EALOX15TSHR | |
| SCHEMBL68594 | 0.65 | NOTUM (0.72) | NOTUMBRD4CYP2D6CYP2C9RAB9A | |
| SCHEMBL6361983 | 0.65 | CES1 (0.44) | CES1NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021163-A1 | QUINAZOLONES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1993-10-28 | — | — | WO | disclosed |