Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.55 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3038425 | 0.83 | ADORA3 (0.43) | BRD4POLBCYP2D6CYP2C19CYP2C9 | |
| SCHEMBL17792927 | 0.79 | POLB (0.42) | BRD4POLBCYP2D6CYP2C19CYP2C9 | |
| SCHEMBL13444609 | 0.73 | ALDH1A1 (0.54) | BRD4POLBCYP2D6CYP2C19CYP2C9 | |
| Bicarbonate SCHEMBL26677806 | 0.67 | BRD4 (0.44) | BRD4POLBKMT2A | |
| SCHEMBL9545365 | 0.67 | NOTUM (0.51) | BRD4AMPD2NOTUMHSD17B3POLB | |
| SCHEMBL18711338 | 0.67 | BRD4 (0.62) | BRD4AMPD2NOTUMHSD17B3POLB | |
| SCHEMBL19051053 | 0.67 | BDKRB2 (0.41) | BRD4NOTUMPOLBKMT2A | |
| Acetic Acid SCHEMBL29250276 | 0.66 | GAA (0.48) | BRD4NOTUMHSD17B3POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3854539 | 0.66 | MAPT (0.48) | KMT2ACYP3A4 | |
| SCHEMBL8793695 | 0.66 | KMT2A (0.42) | HSD17B3POLBCYP2D6CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051967-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | AstraZeneca AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018827-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECEPTOR TRPV1 RELATED DISORDERS | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | WO | disclosed |