Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545365 | 0.79 | NOTUM (0.51) | NOTUMCES1ALDH1A1BRD4CYP2D6 | |
| SCHEMBL677674 | 0.72 | NOTUM (0.60) | NOTUMCES1ALDH1A1BRD4CYP2D6 | |
| Sinitrodil SCHEMBL503115 | 0.69 | TSHR (0.34) | PTGS2ALDH1A1KDM4EMAPTRAB9A | |
| Sinitrodil SCHEMBL31066546 | 0.69 | TSHR (0.34) | PTGS2ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL9166362 | 0.69 | MMP2 (0.34) | PTGS2ALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL3774059 | 0.68 | ALDH1A1 (0.52) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL12043687 | 0.66 | NOTUM (0.55) | NOTUMCES1ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL9188603 | 0.66 | ALDH1A1 (0.56) | PTGS2ALDH1A1CYP2C9KDM4EMAPT | |
| SCHEMBL8658972 | 0.64 | SMN1; SMN2 (0.39) | PTGS2ALDH1A1RECQLKDM4EMAPT | |
| SCHEMBL8636623 | 0.63 | CASP6 (0.41) | ALDH1A1KDM4EMAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021163-A1 | QUINAZOLONES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1993-10-28 | — | — | WO | disclosed |