Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30111084 | 0.77 | KMT2A (0.66) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL30089495 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL19049515 | 0.75 | LMNA (0.61) | SMN1; SMN2RAB9AHTTMAPTLMNA | |
| SCHEMBL875704 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL28866778 | 0.75 | CYP2C9 (0.59) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL874574 | 0.75 | CYP1A2 (0.59) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL30089425 | 0.75 | CYP1A2 (0.59) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL10387888 | 0.75 | HTT (0.74) | SMN1; SMN2RAB9ANPC1HTTLMNA | |
| SCHEMBL15228839 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9AHTTMAPTLMNA | |
| SCHEMBL10387534 | 0.74 | LMNA (0.70) | SMN1; SMN2RAB9ANPC1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021163-A1 | QUINAZOLONES HAVING CARDIOVASCULAR ACTIVITY | ITALFARMACO S.P.A. (IT) | 1993-10-28 | — | — | WO | disclosed |