Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Albuterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 11/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.72 |
| ▸ | TSHR | P16473 | 5/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.61 |
| ▸ | MTOR | P42345 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Albuterol SCHEMBL5657533 | 0.96 | ADRB2 (0.79) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL603953 | 0.93 | ADRB2 (0.82) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Levosalbutamol SCHEMBL18527021 | 0.87 | ADRB2 (0.75) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL9238360 | 0.87 | ADRB2 (0.75) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL122805 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL121596 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL2489838 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Albuterol SCHEMBL4913 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Levosalbutamol SCHEMBL4003 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A | |
| Levosalbutamol SCHEMBL29361075 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1TSHRCYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993019708-A1 | TRANSDERMAL ALBUTEROL ABSORPTION DOSAGE UNIT AND PROCESS | TBS LABORATORIES, INC. (US) | 1993-10-14 | — | — | WO | disclosed |