Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | TOP2A | P11388 | 5/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626483 | 0.92 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL9626565 | 0.90 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10749384 | 0.89 | KDM4E (0.65) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10745550 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9627124 | 0.87 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL29638251 | 0.87 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL8616936 | 0.87 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10584960 | 0.86 | KDM4E (0.39) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| Hydrochloric Acid SCHEMBL10400652 | 0.86 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL10862601 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | claimed |
| JP-5213836-A | — | — | None | — | — | JP | disclosed |
| JP-H05213836-A | 1-AMINO-2,2-DIFLUOROCYCLOPROPANE | BAYER AG | 1993-08-24 | — | — | JP | disclosed |
| EP-0198192-B1 | 7-AMINO-1-(SUBST.CYCLOPROPYL)-1,4 -DIHYDRO-4-OXO-QUINOLINE CARBOXYLIC ACIDS, METHOD FOR THEIR PREPARATION, AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| US-4705788-A | Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | BAYER AKTIENGESELLSCHAFT (DE) | 1987-11-10 | — | — | US | disclosed |