Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843176 | 0.85 | PTGS2 (0.43) | PTGS2MAPK14ALDH1A1PKM | |
| SCHEMBL7841796 | 0.78 | PTGS2 (0.54) | PTGS2MAPK14 | |
| SCHEMBL9548013 | 0.78 | PTGS2 (0.71) | PTGS2MAPK14KDM4EMAPTNPC1 | |
| SCHEMBL7847056 | 0.78 | PTGDR2 (0.48) | PTGS2MAPK14LMNA | |
| SCHEMBL7844988 | 0.77 | PTGS2 (0.52) | PTGS2MAPK14KDM4EMAPTRAB9A | |
| SCHEMBL9547980 | 0.77 | PTGS2 (0.57) | PTGS2MAPK14KDM4EMAPTALDH1A1 | |
| SCHEMBL14380747 | 0.76 | PTGS2 (0.65) | PTGS2MAPK14KDM4EMAPTNPC1 | |
| SCHEMBL9617496 | 0.75 | PTGS2 (0.41) | PTGS2MAPK14ALDH1A1 | |
| SCHEMBL10430827 | 0.74 | PTGS2 (0.42) | PTGS2MAPK14KDM4EMAPTNPC1 | |
| SCHEMBL7844733 | 0.73 | PTGS2 (0.54) | PTGS2MAPK14KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217971-A | Anticoagulants, hypotensive agents, antiallergens and antiinflammatory agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-08 | — | — | US | disclosed |
| EP-0377457-A1 | Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |