Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.71 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843171 | 0.83 | PTGS2 (0.48) | PTGS2MAPK14PTGS1ALOX5 | |
| SCHEMBL14380747 | 0.80 | PTGS2 (0.65) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL5519672 | 0.79 | PTGS2 (0.64) | PTGS2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL5909547 | 0.79 | PTGS2 (0.64) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL9548016 | 0.78 | PTGS2 (0.62) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL7833390 | 0.76 | PTGS2 (0.62) | PTGS2KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL7844983 | 0.76 | PTGS2 (0.62) | PTGS2KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL7841792 | 0.75 | PTGS2 (0.64) | PTGS2MAPK14PTGS1ALOX5 | |
| SCHEMBL5909558 | 0.75 | PTGS2 (0.59) | PTGS2TRPM8KDM4EALDH1A1NPC1 | |
| SCHEMBL5909592 | 0.75 | PTGS2 (0.59) | PTGS2TRPM8KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217971-A | Anticoagulants, hypotensive agents, antiallergens and antiinflammatory agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-08 | — | — | US | disclosed |
| EP-0377457-A1 | Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |