Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724453 | 0.85 | LMNA (0.43) | MEN1KMT2ARXFP1ALDH1A1LMNA | |
| SCHEMBL31586054 | 0.69 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL27809399 | 0.67 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11103793 | 0.67 | CYP3A4 (0.55) | CYP3A4MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL11009791 | 0.66 | CYP3A4 (0.37) | CYP3A4ALDH1A1MAPK10 | |
| SCHEMBL13175569 | 0.64 | HSP90AB1 (0.40) | CYP3A4ALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL31586137 | 0.63 | — | — | |
| SCHEMBL21737795 | 0.63 | — | — | |
| SCHEMBL25281976 | 0.63 | CYP3A4 (0.76) | CYP3A4SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL10863254 | 0.63 | CYP3A4 (0.59) | CYP3A4MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198587-A | Adrenergic Blocking Agents, Hypotensive Agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-30 | — | — | US | disclosed |
| US-5063246-A | Hypotensive | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| US-4880841-A | ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |