Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666458 | 0.78 | PPARA (0.51) | PPARANPSR1MEN1NPC1RAB9A | |
| SCHEMBL11661758 | 0.73 | PPARA (0.60) | PPARANPSR1NPC1RAB9ARXRA | |
| SCHEMBL9548278 | 0.72 | PPARA (0.52) | PPARANPSR1NPC1RAB9AKMT2A | |
| SCHEMBL6402764 | 0.71 | PPARA (0.84) | PPARANPC1RAB9APPARGPPARD | |
| SCHEMBL9849248 | 0.70 | PPARA (0.54) | PPARANPSR1NPC1RAB9AKMT2A | |
| SCHEMBL27348673 | 0.69 | PPARA (0.52) | PPARANPSR1NPC1RAB9AKMT2A | |
| SCHEMBL9665941 | 0.69 | PPARA (0.64) | PPARANPSR1EGFRLMNA | |
| SCHEMBL17747662 | 0.69 | PPARA (0.38) | PPARANR1H4NPSR1S1PR1S1PR3 | |
| SCHEMBL17756209 | 0.69 | PPARA (0.38) | PPARANR1H4NPSR1S1PR1S1PR3 | |
| SCHEMBL9548297 | 0.69 | PPARA (0.52) | PPARANR1H4NPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | claimed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | claimed |
| US-5273989-A | 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| CN-1055537-A | 3, two replacement-2-different azoles alkane of 5-and different azoles, its preparation method contain the preparation and the application thereof of this composition | HOECHST AG (DE) | 1991-10-23 | — | — | CN | disclosed |
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |