Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | C5 | P01031 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27348673 | 0.98 | PPARA (0.52) | PPARANOTUMNPSR1TSHRKEAP1 | |
| SCHEMBL11661758 | 0.89 | PPARA (0.60) | PPARANPSR1TSHRKEAP1RXRA | |
| SCHEMBL9548278 | 0.84 | PPARA (0.52) | PPARANOTUMNPSR1TSHRKEAP1 | |
| SCHEMBL9849445 | 0.83 | PPARA (0.51) | PPARANPSR1TSHRKEAP1RXRA | |
| SCHEMBL9548245 | 0.83 | PPARA (0.41) | PPARANOTUMHDAC6HDAC3HDAC1 | |
| SCHEMBL15581446 | 0.81 | NOTUM (0.44) | PPARANOTUMKDM4ELMNAHPGD | |
| Ammonia Solution, Strong SCHEMBL9548251 | 0.81 | PPARA (0.50) | PPARANPSR1TSHRKEAP1RXRA | |
| SCHEMBL9849579 | 0.80 | PPARA (0.52) | PPARANPSR1TSHRRXRARXRB | |
| SCHEMBL9548297 | 0.80 | PPARA (0.52) | PPARANPSR1TSHRLMNAEPHX2 | |
| Iodide SCHEMBL9548248 | 0.79 | PPARA (0.51) | PPARANPSR1TSHRRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451790-A1 | 3,5-disubstituted 2-isoxazolines and isoxazoles, process for their preparation, medicines containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-16 | — | — | EP | disclosed |