SCHEMBL9548428

SCHEMBL9548428

CC[Si](CC)(CC)OCCC(C)O

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2722071 0.74 HSD17B10 (0.33) TSHRHSD17B10
SCHEMBL2340897 0.73 HSD17B10 (0.31) TSHRHSD17B10
SCHEMBL2046700 0.73 HSD17B10 (0.31) TSHRHSD17B10
SCHEMBL5936772 0.73
SCHEMBL2722133 0.71 CSNK2A1 (0.35) HSD17B10
SCHEMBL14228366 0.69
SCHEMBL10431668 0.69 HSD17B10 (0.33) HSD17B10
SCHEMBL1313910 0.68 MAPK1 (0.33)
SCHEMBL1313907 0.68 MAPK1 (0.33)
SCHEMBL29050148 0.68 LMNA (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0336143-B1 A NEW PROCESS FOR CARBAPENEM INTERMEDIATES SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1993-06-09 EP disclosed
US-4960879-A REACTING SUBSTITUTED AZETIDINONE WITH TRANS SUBSTITUTED-METHYL ALKYLACRYLIC ACID AND REDUCING METAL SHIONOGI & CO., LTD. (JP) 1990-10-02 US disclosed
EP-0336143-A1 A new process for carbapenem intermediates SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) 1989-10-11 EP disclosed