Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231282 | 0.90 | TSHR (0.61) | ALDH1A1TSHRRAB9AL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL7053203 | 0.88 | TSHR (0.58) | ALDH1A1TSHRRAB9AL3MBTL1NPC1 | |
| SCHEMBL4226282 | 0.88 | TSHR (0.58) | ALDH1A1TSHRRAB9AL3MBTL1NPC1 | |
| Acetic Acid SCHEMBL28567289 | 0.87 | ALDH1A1 (0.55) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL21657315 | 0.86 | FFAR4 (0.44) | ALDH1A1RAB9ASMN1; SMN2L3MBTL1GLA | |
| SCHEMBL29928468 | 0.86 | FFAR4 (0.44) | ALDH1A1RAB9ASMN1; SMN2L3MBTL1GLA | |
| Ethylbenzene SCHEMBL27718341 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 | |
| Ether SCHEMBL10609432 | 0.82 | TSHR (0.75) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 | |
| Ether SCHEMBL19744986 | 0.82 | TSHR (0.75) | ALDH1A1TSHRRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1956559 | 0.81 | TSHR (0.54) | ALDH1A1TSHRSMN1; SMN2L3MBTL1PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009429-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | NOVARTIS AG (CH) | 2011-01-13 | — | — | US | disclosed |
| EP-2257552-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | Novartis AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106539-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009429-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | CXCR2, CXCR1, CXCR3 | ALDH1A1 1082/4885TSHR 1428/4885RAB9A 1699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.