Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9549838 | 0.96 | HIF1A (0.52) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Phosphoric Acid SCHEMBL9549648 | 0.88 | HIF1A (0.44) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Acetic Acid SCHEMBL9549690 | 0.87 | ALDH1A1 (0.46) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL9549849 | 0.82 | HIF1A (0.54) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Bromide SCHEMBL143506 | 0.82 | HIF1A (0.58) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9549668 | 0.78 | HIF1A (0.54) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL9549567 | 0.78 | HIF1A (0.58) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Iodide SCHEMBL9549744 | 0.78 | HIF1A (0.58) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| Water SCHEMBL8528580 | 0.78 | HIF1A (0.58) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 | |
| SCHEMBL8532850 | 0.78 | HIF1A (0.58) | HIF1AHTR2AHRH1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208317-A | Molding materials of cured epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5109099-A | ADVANCING EPOXY RESINS IN PRESENCE OF AMINO GROUP-CONTAINING PHOSPHONIUM CATALYST | THE DOW CHEMICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0441243-A2 | Precatalyzed catalyst compositions, process for preparing epoxy resins, curable compositions, articles resulting from curing the resultant compositions | THE DOW CHEMICAL COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4981926-A | Rapid and selective curing using phosphonium catalyst containing an amine group; polyepoxides | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |