Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9549758 | 0.96 | CARM1 (0.55) | CARM1PRMT6PRMT8SIGMAR1HIF1A | |
| Phosphoric Acid SCHEMBL9549658 | 0.89 | SIGMAR1 (0.47) | CARM1PRMT6PRMT8SIGMAR1HIF1A | |
| Acetic Acid SCHEMBL9549681 | 0.88 | CARM1 (0.46) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| Bromide SCHEMBL143506 | 0.79 | HIF1A (0.58) | HIF1ATSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7055109 | 0.78 | CARM1 (0.75) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL8297797 | 0.78 | HTR2A (0.62) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL14578374 | 0.76 | CARM1 (0.60) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| SCHEMBL9750655 | 0.75 | HTR2A (0.58) | CARM1PRMT6PRMT8SIGMAR1TSHR | |
| Iodide SCHEMBL9549744 | 0.75 | HIF1A (0.58) | HIF1ATSHRALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9549567 | 0.75 | HIF1A (0.58) | SIGMAR1HIF1ATSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208317-A | Molding materials of cured epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5109099-A | ADVANCING EPOXY RESINS IN PRESENCE OF AMINO GROUP-CONTAINING PHOSPHONIUM CATALYST | THE DOW CHEMICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0441243-A2 | Precatalyzed catalyst compositions, process for preparing epoxy resins, curable compositions, articles resulting from curing the resultant compositions | THE DOW CHEMICAL COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4981926-A | Rapid and selective curing using phosphonium catalyst containing an amine group; polyepoxides | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |