Phosphoric Acid

SCHEMBL9549605

CC(C)N(CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(C)C.CC(C)N(CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(C)C.CC(C)N(CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C(C)C.O=P([O-])([O-])[O-]

nearest known ligand 0.45

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Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	HRH1 known ✓	P35367	4/20	0.38

▸	ADRA1A known ✓	P35348	1/20	0.38

▸	OPRK1 known ✓	P41145	1/20	0.38

▸	KCNQ1 known ✓	P51787	1/20	0.38

▸	KCNH2 known ✓	Q12809	1/20	0.38

▸	SCN5A known ✓	Q14524	1/20	0.38

▸	KCND3 known ✓	Q9UK17	1/20	0.38

▸	ADRB2 known ✓	P07550	1/20	0.35

▸	HIF1A	Q16665	1/20	0.45

▸	ALDH1A1	P00352	2/20	0.41

▸	CYP1A2	P05177	1/20	0.41

▸	CYP2D6	P10635	1/20	0.41

▸	TSHR	P16473	1/20	0.41

▸	CYP2C19	P33261	1/20	0.41

▸	CHRM2	P08172	3/20	0.38

▸	CHRM1	P11229	3/20	0.38

▸	CHRM3	P20309	3/20	0.38

▸	HTR2A	P28223	3/20	0.38

▸	CHRM5	P08912	2/20	0.38

▸	LMNA	P02545	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Hydrochloric Acid SCHEMBL9549668	0.88	HIF1A (0.54)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Bromide SCHEMBL9549849	0.88	HIF1A (0.54)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Phosphoric Acid SCHEMBL9549648	0.85	HIF1A (0.44)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Acetic Acid SCHEMBL9549671	0.85	TSHR (0.47)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Acetic Acid SCHEMBL9848342	0.84	TSHR (0.46)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Phosphoric Acid SCHEMBL8972371	0.83	HTR2A (0.50)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Phosphoric Acid SCHEMBL9067723	0.77	HIF1A (0.54)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Phosphoric Acid SCHEMBL9549586	0.77	HTR2A (0.47)	HIF1AALDH1A1CYP1A2CYP2D6TSHR
Phosphoric Acid SCHEMBL9549658	0.76	SIGMAR1 (0.47)	HIF1ASIGMAR1TMEM97
Butyltriphenylphosphonium SCHEMBL8972698	0.75	HIF1A (0.52)	HIF1AALDH1A1CYP1A2CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5208317-A	Molding materials of cured epoxy resins	THE DOW CHEMICAL COMPANY (US)	1993-05-04	—	—	US	disclosed
US-5109099-A	ADVANCING EPOXY RESINS IN PRESENCE OF AMINO GROUP-CONTAINING PHOSPHONIUM CATALYST	THE DOW CHEMICAL COMPANY (US)	1992-04-28	—	—	US	disclosed
EP-0441243-A2	Precatalyzed catalyst compositions, process for preparing epoxy resins, curable compositions, articles resulting from curing the resultant compositions	THE DOW CHEMICAL COMPANY (US)	1991-08-14	—	—	EP	disclosed
US-4981926-A	Rapid and selective curing using phosphonium catalyst containing an amine group; polyepoxides	THE DOW CHEMICAL COMPANY (US)	1991-01-01	—	—	US	disclosed