Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.46 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9549787 | 0.96 | SIGMAR1 (0.61) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Bromide SCHEMBL9851216 | 0.91 | SIGMAR1 (0.58) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Phosphoric Acid SCHEMBL9549735 | 0.90 | SIGMAR1 (0.54) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Bromide SCHEMBL9239994 | 0.89 | SIGMAR1 (0.56) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Acetic Acid SCHEMBL9549728 | 0.88 | SIGMAR1 (0.51) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Acetic Acid SCHEMBL9848338 | 0.86 | SIGMAR1 (0.50) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| SCHEMBL8536686 | 0.83 | SIGMAR1 (0.56) | SIGMAR1HIF1AKCNH2CHRM1SLC6A2 | |
| Hydrochloric Acid SCHEMBL9549516 | 0.81 | HTR2A (0.53) | SIGMAR1HIF1ASLC6A2SLC6A4CHRM2 | |
| Hydrochloric Acid SCHEMBL6060715 | 0.80 | HIF1A (0.74) | HIF1AALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5091467 | 0.79 | HIF1A (0.58) | HIF1AALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208317-A | Molding materials of cured epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5109099-A | ADVANCING EPOXY RESINS IN PRESENCE OF AMINO GROUP-CONTAINING PHOSPHONIUM CATALYST | THE DOW CHEMICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0441243-A2 | Precatalyzed catalyst compositions, process for preparing epoxy resins, curable compositions, articles resulting from curing the resultant compositions | THE DOW CHEMICAL COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4981926-A | Rapid and selective curing using phosphonium catalyst containing an amine group; polyepoxides | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |