Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28063285 | 0.80 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL8337805 | 0.77 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL27734208 | 0.77 | CA1 (0.39) | HCAR2KEAP1NFE2L2TDP1 | |
| SCHEMBL27733994 | 0.77 | CA1 (0.39) | HCAR2KEAP1NFE2L2TDP1 | |
| SCHEMBL8712030 | 0.77 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2ALDH1A1MAPT | |
| SCHEMBL27839789 | 0.75 | ALDH1A1 (0.37) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| SCHEMBL365676 | 0.72 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL12475705 | 0.72 | — | — | |
| SCHEMBL8519665 | 0.72 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2MAPTLMNA | |
| SCHEMBL18763355 | 0.72 | ALDH1A1 (0.35) | HCAR2KEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | claimed |
| US-5264575-A | Reacting 1,3-benzodiazocine-8-ol derivative with lutidine/2,6-/, triisoproylsilyltrifluoro methane, formed intermediate reacted with lithium chloride, tetrabutylammonium fluoride and isocyanate | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5097033-A | Aminoethyl quinoline 2-ones, intermediates for analgesic, and cholinergic agents for memory disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | disclosed |