Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519665 | 1.00 | HCAR2 (0.43) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL8519666 | 0.90 | HCAR2 (0.52) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL8519669 | 0.90 | HCAR2 (0.52) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL28308759 | 0.86 | KEAP1 (0.33) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL28767804 | 0.80 | HCAR2 (0.41) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL1072996 | 0.80 | HCAR2 (0.41) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL27806772 | 0.80 | — | — | |
| SCHEMBL28863331 | 0.79 | LMNA (0.36) | HCAR2KEAP1NFE2L2RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL28364947 | 0.78 | HCAR2 (0.39) | HCAR2KEAP1NFE2L2MAPTCACNA1B | |
| SCHEMBL32691366 | 0.78 | TSHR (0.43) | MAPTCACNA1BAPBA1TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009538-A2 | ADIPOCYTE-DERIVED MEMBRANE EXTRACT WITH BIOLOGICAL ACTIVITY | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-01-19 | — | — | WO | disclosed |
| CN-101031548-B | Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy) phenylmethyl) carbamide and their preparation | ACADIA PHARM INC | 2011-04-06 | — | — | CN | disclosed |
| CN-1147469-C | Novel urea derivatives bearing nitrogenous aromatic heterocycles | ������ҩ��ʽ���� | 2004-04-28 | — | — | CN | disclosed |
| CN-1318051-A | Novel urea derivative having aromatic nitrogen-containing heterocycle | SANTEN PHARMACEUTICAL CO LTD (JP) | 2001-10-17 | — | — | CN | disclosed |