Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.80 |
| ▸ | DRD4 | P21917 | 2/20 | 0.70 |
| ▸ | DRD3 | P35462 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9549997 | 1.00 | DRD2 (0.80) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL11163460 | 0.93 | DRD2 (0.88) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL9550072 | 0.92 | DRD2 (0.80) | DRD2DRD4DRD3 | |
| SCHEMBL9550077 | 0.92 | DRD2 (0.80) | DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10691937 | 0.92 | DRD2 (0.86) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL9549931 | 0.89 | DRD2 (1.00) | DRD2 | |
| SCHEMBL9550067 | 0.89 | DRD2 (0.85) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL9549949 | 0.89 | DRD2 (1.00) | DRD2 | |
| SCHEMBL9550074 | 0.89 | DRD2 (0.85) | DRD2DRD4DRD3MEN1HTR1A | |
| SCHEMBL11168904 | 0.88 | DRD2 (0.80) | DRD2DRD4DRD3MEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5240957-A | Dopaminergic agent | ASTRA LAKEMEDEL AKTEIBOLAG (SE) | 1993-08-31 | — | — | US | disclosed |
| EP-0156776-A1 | Derivatives of N-(2-pyrrolidinylmethyl)-benzamide, process for their preparation, intermediates and a pharmaceutical preparation | Astra Läkemedel Aktiebolag (SE) | 1985-10-02 | — | — | EP | disclosed |