Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709981 | 0.85 | L3MBTL1 (0.65) | TSHRL3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL5710171 | 0.85 | L3MBTL1 (0.65) | TSHRL3MBTL1ALDH1A1LMNAPOLB | |
| SCHEMBL17737178 | 0.81 | TSHR (0.60) | TSHRL3MBTL1POLBMAPT | |
| Chlorobenzene SCHEMBL9550104 | 0.80 | HTT (0.56) | TSHRALDH1A1LMNACYP3A4MAPK1 | |
| SCHEMBL11776327 | 0.79 | TSHR (0.63) | TSHRL3MBTL1ALDH1A1POLBMAPT | |
| Dodeclonium SCHEMBL16049443 | 0.78 | HTT (0.73) | TSHRALDH1A1LMNACYP3A4MAPK1 | |
| Dodeclonium SCHEMBL29385158 | 0.76 | KCNH2 (0.72) | TSHRALDH1A1LMNACYP3A4MAPK1 | |
| Bromide SCHEMBL11134680 | 0.76 | KCNH2 (0.67) | TSHRALDH1A1LMNACYP3A4MAPK1 | |
| Bromide SCHEMBL10492800 | 0.76 | DGKA (0.65) | TSHRALDH1A1LMNACYP3A4MAPK1 | |
| Bromide SCHEMBL11579096 | 0.76 | DGKA (0.65) | TSHRALDH1A1LMNACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5058971-A | — | — | None | — | — | JP | disclosed |
| JP-H0558971-A | AMINOESTER COMPOUND SALT AND DISINFECTANT | OTSUKA PHARMACEUT CO LTD | 1993-03-09 | — | — | JP | disclosed |