⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10644282 | 0.74 | — | — | |
| SCHEMBL20024572 | 0.65 | — | — | |
| SCHEMBL4577346 | 0.65 | — | — | |
| SCHEMBL19655630 | 0.63 | L3MBTL1 (0.31) | — | |
| SCHEMBL18157872 | 0.63 | L3MBTL1 (0.35) | — | |
| SCHEMBL19939409 | 0.63 | KDM4E (0.35) | — | |
| SCHEMBL19662723 | 0.61 | L3MBTL1 (0.31) | — | |
| SCHEMBL22445278 | 0.53 | — | — | |
| SCHEMBL21621541 | 0.53 | — | — | |
| SCHEMBL8506296 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148332-A1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-05-28 | — | — | US | claimed |
| CN-104364249-A | Triazolo compounds as pde10 inhibitors | BOSCH GMBH ROBERT | 2015-02-18 | — | — | CN | claimed |
| WO-2023073115-A1 | PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2023-05-04 | — | — | WO | disclosed |
| EP-4173485-A1 | PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2023-05-03 | — | — | EP | disclosed |
| CN-104364249-B | Triazol compound as PDE10 inhibitor | 霍夫曼-拉罗奇有限公司 | 2018-04-17 | — | — | CN | disclosed |
| EP-2855455-A1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| CN-104364249-A | Triazolo compounds as pde10 inhibitors | BOSCH GMBH ROBERT | 2015-02-18 | — | — | CN | disclosed |
| WO-2013178572-A1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-12-05 | — | — | WO | disclosed |
| CN-102482227-A | Substituted Triazole And Imidazole Derivatives As Gamma Secretase Modulators | ORTHO MCNEIL JANSSEN PHARM | 2012-05-30 | — | — | CN | disclosed |
| EP-2454239-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Janssen Pharmaceuticals Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011006903-A1 | SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2011-01-20 | — | — | WO | disclosed |