Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HPN | P05981 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698130 | 0.84 | ALOX15 (0.63) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL646923 | 0.82 | ALOX15 (0.61) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9504462 | 0.82 | ALOX15 (0.61) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL10503818 | 0.80 | ALOX15 (0.63) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL11739235 | 0.79 | ALOX15 (0.57) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9852829 | 0.78 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9168124 | 0.78 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9165330 | 0.78 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9769341 | 0.78 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL8390050 | 0.76 | MAPT (0.53) | ALOX15HPNMAPTSIRT5CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5208262-A | Administering 4-hydroxythiophenol derivatives | G. D. SEARLE & CO. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0218782-B1 | LIPOXYGENASE-INHIBITING COMPOSITION AND HYDROXYPHENYLTHIOALKYLCARBONYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0218782-A1 | Lipoxygenase-inhibiting composition and hydroxyphenylthioalkylcarbonyl compounds | G.D. Searle & Co. (US) | 1987-04-22 | — | — | EP | disclosed |