Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | HPN | P05981 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698130 | 0.89 | ALOX15 (0.63) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL10706853 | 0.89 | CYP2C9 (0.53) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9504462 | 0.88 | ALOX15 (0.61) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL10503818 | 0.85 | ALOX15 (0.63) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL11739235 | 0.84 | ALOX15 (0.57) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9852829 | 0.82 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9769341 | 0.82 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9165330 | 0.82 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9550779 | 0.82 | ALOX15 (0.55) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9168124 | 0.82 | HPN (0.55) | ALOX15HPNMAPTSIRT5CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070919-B1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LAB LLC (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-8119686-B2 | Spiroquinone compound and pharmaceutical composition | HYKES LABORATORIES LLC (JP) | 2012-02-21 | — | — | US | disclosed |
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LABORATORIES LLC (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2070919-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | Hykes Laboratories LLC (JP) | 2009-06-17 | — | — | EP | disclosed |
| EP-0372542-A2 | Hypocholesterolemic and antiatherosclerotic uses of bis (3,5-di-tertiary-butyl-4-hydroxyphenylthio) methane | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | NR1H2, NR1H3, APOB | ALOX15 2563/4885HPN 3356/4885MAPT 4362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.