Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC33A1 | O00400 | 2/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9553197 | 0.89 | SLC33A1 (0.35) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9552746 | 0.88 | SLC33A1 (0.36) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9552478 | 0.88 | SLC33A1 (0.36) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9553327 | 0.87 | SLC33A1 (0.35) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9553553 | 0.86 | AGTR1 (0.37) | TRPV1SLC33A1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL9552076 | 0.86 | SLC33A1 (0.35) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9552812 | 0.86 | SLC33A1 (0.38) | TRPV1SLC33A1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL9552356 | 0.86 | RIPK1 (0.37) | ALDH1A1TRPV1SLC33A1KCNJ6KCNJ5 | |
| SCHEMBL9552169 | 0.85 | AGTR1 (0.35) | SLC33A1S1PR1AGTR1 | |
| SCHEMBL9553055 | 0.85 | SLC33A1 (0.36) | ALDH1A1TRPV1MEN1KMT2ASLC33A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229406-A | Treatment of glaucoma | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5140036-A | Hypotensive agents; congestive heart failure; angiotensin antagonists | G. D. SEARLE & CO. (US) | 1992-08-18 | — | — | US | disclosed |
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |