Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL344009 | 0.95 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| SCHEMBL171879 | 0.92 | KMT2A (0.54) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| SCHEMBL15571095 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| SCHEMBL15571863 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| Bromide SCHEMBL30536669 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| SCHEMBL15571321 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| Iodide SCHEMBL11884469 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| SCHEMBL15571880 | 0.90 | KMT2A (0.52) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 | |
| Bromide SCHEMBL11429835 | 0.90 | KMT2A (0.58) | KMT2AHSP90AA1PABPC1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL614210 | 0.80 | KMT2A (0.48) | KMT2AHSP90AA1PABPC1KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185247-A | Qualitative or quantitative analysis of glucose, cholesterol, uric acid or lower alcohols in a fluid sample by contacting with a reagent containing an oxidase, an oxidizable chromogen, peroxidase, a buffer and a hydarzine for colorimetric analysis | MILES INC. (US) | 1993-02-09 | — | — | US | claimed |