Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562270 | 0.97 | KMT2A (0.50) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrazine SCHEMBL9553603 | 0.80 | KMT2A (0.48) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL19031444 | 0.79 | KMT2A (0.52) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL344009 | 0.79 | KMT2A (0.52) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL28662728 | 0.76 | MEN1 (0.36) | KMT2AKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL19037380 | 0.76 | KMT2A (0.54) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| SCHEMBL171879 | 0.76 | KMT2A (0.54) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL420325 | 0.75 | KMT2A (0.54) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E | |
| Hydrochloric Acid SCHEMBL713375 | 0.75 | HSP90AA1 (0.53) | KMT2AHSP90AA1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL15571095 | 0.74 | KMT2A (0.52) | KMT2ACYP2C9HSP90AA1PABPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116875980-A | Copper-reducing additive for HDI board and copper-reducing process | 上海天承化学有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-106758498-B | Water resistant oil resistant Cationic dispersed rosin size | 南昌市龙然实业有限公司 | 2018-02-13 | — | — | CN | claimed |
| CN-106592335-B | Cation colophony size for food wrapper | 南昌市龙然实业有限公司 | 2018-02-13 | — | — | CN | claimed |
| CN-106758498-A | Water resistant oil resistant Cationic dispersed rosin size | 南昌市龙然实业有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106592335-A | Novel cation rosin sizing agent used for food packaging paper | 南昌市龙然实业有限公司 | 2017-04-26 | — | — | CN | claimed |
| US-12404274-B2 | Macrocycles as factor xia inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-09-02 | — | — | US | disclosed |
| CN-120129707-A | Solid particles of silicone-functional copolymer, method for producing same, and cosmetic containing same | 陶氏东丽株式会社 | 2025-06-10 | — | — | CN | disclosed |
| US-20240298520-A1 | ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES | UNIVERSAL DISPLAY CORPORATION (US) | 2024-09-05 | — | — | US | disclosed |
| CN-116875980-A | Copper-reducing additive for HDI board and copper-reducing process | 上海天承化学有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-107973809-B | Macrocyclic compounds as factor XIA inhibitors | 百时美施贵宝公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230058729-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2023-02-23 | — | — | US | disclosed |
| EP-3810596-B1 | QUINOLINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-11-30 | — | — | EP | disclosed |
| EP-0540604-A1 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | Aventis Pharma S.A. (FR) | 1993-05-12 | — | — | EP | disclosed |
| US-5155114-A | Treating or preventing renal toxicity, nephrosis, nephritis | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| WO-1992001675-A2 | SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |
| US-4985444-A | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| EP-0379979-A1 | Pyrazolopyridine compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |
| US-4136033-A | DIAZO COUPLERS | SANDOZ LTD. (CH) | 1979-01-23 | — | — | US | disclosed |
| US-4105665-A | MONOMETHINE DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-08-08 | — | — | US | disclosed |
| US-4018796-A | FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404274-B2 | Macrocycles as factor xia inhibitors | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885CYP2C9 1012/4885 |
| US-20230058729-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F11 | ACHE 3298/4885KMT2A 1111/4885CYP2C9 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.