Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.47 |
| ▸ | METAP2 | P50579 | 6/20 | 0.36 |
| ▸ | METAP1 | P53582 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9554531 | 1.00 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL7292635 | 1.00 | REN (0.47) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9554869 | 0.99 | REN (0.46) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9554876 | 0.99 | REN (0.46) | RENMETAP2METAP1 | |
| SCHEMBL7368680 | 0.85 | REN (0.50) | RENMETAP2METAP1 | |
| SCHEMBL7327540 | 0.81 | REN (0.53) | RENMETAP2METAP1 | |
| SCHEMBL7301121 | 0.80 | REN (0.50) | RENMETAP2METAP1 | |
| SCHEMBL7269758 | 0.79 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL7269766 | 0.79 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL7268680 | 0.79 | REN (0.47) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0310918-A2 | Peptide-like amino-acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-12 | — | — | EP | disclosed |