Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 7/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 4/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555013 | 0.94 | REN (0.45) | RENBACE1CCKBRBACE2CCKAR | |
| SCHEMBL5891507 | 0.90 | EGFR (0.46) | RENCTSDBACE1KLK5CCKBR | |
| SCHEMBL9555318 | 0.86 | REN (0.51) | RENCTSDBACE1KLK5BACE2 | |
| SCHEMBL9555315 | 0.86 | REN (0.51) | RENCTSDBACE1KLK5BACE2 | |
| SCHEMBL5891920 | 0.84 | FNTA (0.52) | RENBACE1 | |
| SCHEMBL9074456 | 0.82 | REN (0.54) | RENBACE1KLK5BACE2 | |
| SCHEMBL9555357 | 0.81 | REN (0.52) | RENBACE1BACE2 | |
| SCHEMBL9555141 | 0.80 | REN (0.51) | RENBACE1BACE2 | |
| SCHEMBL9555135 | 0.80 | REN (0.51) | RENBACE1BACE2 | |
| SCHEMBL8073153 | 0.80 | EGFR (0.47) | RENCTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238922-A | Anticancer agents | MERCK & CO., INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0535731-A2 | Inhibitors of farnesyl protein transferase | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | disclosed |