Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 12/20 | 0.49 |
| ▸ | FNTA | P49354 | 2/20 | 0.47 |
| ▸ | FNTB | P49356 | 2/20 | 0.47 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555141 | 1.00 | REN (0.51) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL9555318 | 0.94 | REN (0.51) | RENBACE1BACE2 | |
| SCHEMBL9555315 | 0.94 | REN (0.51) | RENBACE1BACE2 | |
| SCHEMBL9555288 | 0.90 | FNTA (0.54) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL9555294 | 0.90 | FNTA (0.54) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL9555013 | 0.86 | REN (0.45) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL31091378 | 0.83 | ACE (0.59) | REN | |
| SCHEMBL9074456 | 0.83 | REN (0.54) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL9555357 | 0.82 | REN (0.52) | RENBACE1FNTAFNTBPGGT1B | |
| SCHEMBL23154872 | 0.81 | CTSS (0.58) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238922-A | Anticancer agents | MERCK & CO., INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0535731-A2 | Inhibitors of farnesyl protein transferase | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | disclosed |