Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453226 | 0.97 | MAPT (0.35) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| Bromide SCHEMBL9757561 | 0.94 | RAB9A (0.37) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| SCHEMBL19458298 | 0.80 | TP53 (0.33) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL31265533 | 0.72 | MAPT (0.39) | MAPTKDM4ERAB9AALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11427015 | 0.72 | HTT (0.48) | MAPTHTTKDM4ERAB9ATP53 | |
| SCHEMBL21694123 | 0.72 | NPC1 (0.47) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| SCHEMBL9555495 | 0.69 | MAPT (0.41) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| SCHEMBL17768446 | 0.69 | KDM4E (0.35) | MAPTHTTKDM4ERAB9AALDH1A1 | |
| Bromide SCHEMBL8662929 | 0.67 | HTT (0.48) | MAPTHTTKDM4ERAB9ATP53 | |
| SCHEMBL1049882 | 0.67 | KDM4E (0.53) | MAPTHTTKDM4ERAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0339535-B1 | PLATING BATH FOR ELECTRODEPOSITION OF ALUMINUM AND PLATING PROCESS MAKING USE OF THE BATH | NISSHIN STEEL CO., LTD. (JP) | 1993-09-08 | — | — | EP | disclosed |
| US-4906342-A | Plating bath for electrodeposition of aluminum and plating process making use of the bath | NISSHIN STEEL CO., LTD. (JP) | 1990-03-06 | — | — | US | disclosed |
| EP-0339535-A1 | Plating bath for electrodeposition of aluminum and plating process making use of the bath | NISSHIN STEEL CO., LTD. (JP) | 1989-11-02 | — | — | EP | disclosed |