Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294622 | 0.82 | SORD (0.51) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL2074811 | 0.79 | SORD (0.51) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL23374607 | 0.79 | HRH3 (0.55) | SORDKDM4EHRH3DRD2DRD3 | |
| SCHEMBL31140251 | 0.79 | HRH3 (0.55) | SORDKDM4EHRH3DRD2DRD3 | |
| SCHEMBL3137995 | 0.79 | HRH3 (0.52) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL6183959 | 0.78 | SORD (0.51) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL3145713 | 0.78 | SORD (0.48) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL26436593 | 0.78 | SORD (0.51) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL19035675 | 0.77 | HRH3 (0.47) | SORDKDM4EDRD4HRH3DRD2 | |
| SCHEMBL19035627 | 0.77 | HTR1A (0.46) | SORDKDM4EDRD4HRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215967-A | AMINOACID DERIVATIVES INHIBITING RENIN | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0371390-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1990-06-06 | — | — | EP | disclosed |