Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558735 | 0.99 | MAPT (0.57) | MAPTKDM4EALDH1A1NPSR1USP2 | |
| SCHEMBL9558674 | 0.97 | MAPT (0.58) | MAPTKDM4EALDH1A1NPSR1USP2 | |
| SCHEMBL24698171 | 0.86 | ALDH1A1 (0.54) | MAPTKDM4EALDH1A1NPSR1POLB | |
| SCHEMBL9558721 | 0.84 | ALDH1A1 (0.59) | KDM4EALDH1A1NPSR1CASP1CASP7 | |
| SCHEMBL9558892 | 0.83 | LMNA (0.56) | MAPTKDM4EALDH1A1NPSR1CASP1 | |
| SCHEMBL9559101 | 0.83 | ALDH1A1 (0.58) | KDM4EALDH1A1NPSR1USP2POLB | |
| SCHEMBL9559080 | 0.83 | ALDH1A1 (0.58) | KDM4EALDH1A1NPSR1USP2POLB | |
| SCHEMBL9558635 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1NPSR1USP2CASP1 | |
| SCHEMBL11399146 | 0.79 | HRH4 (0.67) | NPSR1POLBHRH4SMN1; SMN2HSD17B10 | |
| SCHEMBL11388985 | 0.76 | HRH4 (0.67) | HRH4SMN1; SMN2HSD17B10HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185338-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| EP-0484988-A1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-05-13 | — | — | EP | disclosed |
| US-5041443-A | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0384228-A1 | Medicament for treating cerebral insufficiency diseases containing 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-08-29 | — | — | EP | disclosed |