Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9559413 | 0.88 | HSD17B10 (0.43) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9559370 | 0.84 | PIK3CB (0.42) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9559357 | 0.82 | PDE3B (0.45) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9833576 | 0.77 | PDE4A (0.49) | HSD17B10KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL9559252 | 0.75 | PIK3CB (0.41) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9833587 | 0.71 | KDM4E (0.41) | HSD17B10KDM4EALDH1A1TP53TSHR | |
| SCHEMBL11020209 | 0.71 | HPGD (0.47) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9559267 | 0.69 | PDE3B (0.55) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9559277 | 0.69 | ALDH1A1 (0.43) | HSD17B10KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL9831445 | 0.68 | MAPT (0.50) | HSD17B10KDM4EALDH1A1HPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334289-B1 | HETEROCYCLIC SUBSTITUTED 5,7-DIHYDROPYRROLO (3,2-F) BENZOXAZOL-6-ONES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAME | Roche Diagnostics GmbH (DE) | 1993-06-16 | — | — | EP | disclosed |
| US-5057526-A | Immunological disorders, suppress organ rejection | BOEHRINGER MANNHEIM GMBH (DE) | 1991-10-15 | — | — | US | disclosed |