Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 13/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | BID | P55957 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9560060 | 0.90 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1PPARAS1PR2S1PR1 | |
| SCHEMBL9561606 | 0.79 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1PPARABIDMCL1 | |
| SCHEMBL9507481 | 0.79 | CYSLTR2 (0.71) | CYSLTR2CYSLTR1 | |
| SCHEMBL9561464 | 0.77 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1PPARABIDMCL1 | |
| SCHEMBL9559976 | 0.77 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1PPARABIDMCL1 | |
| SCHEMBL9561450 | 0.77 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1PPARABIDMCL1 | |
| SCHEMBL9560080 | 0.76 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1 | |
| SCHEMBL9560041 | 0.75 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1PPARABIDMCL1 | |
| SCHEMBL21240867 | 0.75 | CYSLTR2 (0.61) | CYSLTR2CYSLTR1PPARAS1PR2S1PR1 | |
| SCHEMBL9504738 | 0.75 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1PPARABIDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4937253-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-26 | — | — | US | claimed |
| EP-0365149-A2 | Leukotriene antagonist prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-25 | — | — | EP | claimed |
| CN-1041359-A | PROCESS FOR PREPARING LEUKOTRIENE ANTAGONIST PRODRUGS | SMITHKLINE BECKMAN CORP (US) | 1990-04-18 | — | — | CN | claimed |
| CN-1025564-C | Process for the preparation of phenyl epoxy hydroxy acid esters | SMITHKLINE BECKMAN CORP (US) | 1994-08-03 | — | — | CN | disclosed |
| EP-0358240-B1 | INTERMEDIATES FOR THE PREPARATION OF LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-09 | — | — | EP | disclosed |
| US-5189226-A | Chemical intermediate for diacid | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-23 | — | — | US | disclosed |
| US-5034537-A | Alpha-methyl-4-halobenzenemethanamine salts of acids for cardiovascular disorders, respiratory system disorders and antiallergens | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-23 | — | — | US | disclosed |
| US-4939279-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |
| US-4937253-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-26 | — | — | US | disclosed |
| EP-0202759-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-20 | — | — | EP | disclosed |
| CN-1008091-B | Process for preparing leukotriene antagonists | SMITHKLINE BECKMAN CORP (US) | 1990-05-23 | — | — | CN | disclosed |
| EP-0365149-A2 | Leukotriene antagonist prodrugs | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |
| CN-1041359-A | PROCESS FOR PREPARING LEUKOTRIENE ANTAGONIST PRODRUGS | SMITHKLINE BECKMAN CORP (US) | 1990-04-18 | — | — | CN | disclosed |
| CN-1040586-A | Process for preparing leukotriene antagonists | SMITHKLINE BECKMAN CORP (US) | 1990-03-21 | — | — | CN | disclosed |
| EP-0358240-A2 | Intermediates for the preparation of leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4874792-A | RESPIRATORY SYSTEM DISORDERS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4820719-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIISCHEMIC AND HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| CN-86102482-A | Process for preparing leukotriene antagonists | — | 1987-02-04 | — | — | CN | disclosed |
| EP-0202759-A2 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1986-11-26 | — | — | EP | disclosed |