Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9128160 | 0.95 | HIF1A (0.52) | MRGPRX4HIF1AMAOBKDM4ENPC1 | |
| SCHEMBL490469 | 0.91 | MRGPRX4 (0.62) | MRGPRX4HIF1AMAOBKDM4ENPC1 | |
| SCHEMBL31123658 | 0.83 | ALDH1A1 (0.60) | HIF1AKDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL10920926 | 0.81 | ALDH1A1 (0.53) | HIF1AMAOBKDM4ERAB9AALDH1A1 | |
| SCHEMBL28605556 | 0.81 | ALDH1A1 (0.50) | MAOBKDM4ENPC1RAB9ANR4A2 | |
| SCHEMBL3134818 | 0.80 | SLC6A3 (0.52) | MAOBKDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL4002760 | 0.79 | HIF1A (0.56) | MRGPRX4HIF1AMAOBKDM4EALDH1A1 | |
| SCHEMBL9561905 | 0.79 | ALDH1A1 (0.64) | MRGPRX4HIF1AKDM4EALDH1A1FOLH1 | |
| SCHEMBL1760329 | 0.78 | PTGER4 (0.51) | MRGPRX4HIF1ANR4A2ALDH1A1KMT2A | |
| SCHEMBL4452776 | 0.77 | HIF1A (0.61) | MRGPRX4HIF1ANPC1RAB9ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409406-B1 | ARYL-SUBSTITUTED AMINE DERIVATIVES USEFUL IN CANCER THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-08 | — | — | EP | disclosed |