Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MIF | P14174 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918267 | 0.92 | MAPK14 (0.55) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL7249247 | 0.82 | ALDH1A1 (0.69) | MAPTALDH1A1RAB9ATDP1L3MBTL1 | |
| SCHEMBL490119 | 0.82 | AKR1B1 (0.58) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL7246016 | 0.80 | TDP1 (0.64) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL9561892 | 0.80 | ALDH1A1 (0.46) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL3142640 | 0.79 | MAPT (0.72) | MAPTALDH1A1RAB9ATDP1L3MBTL1 | |
| SCHEMBL8882817 | 0.77 | AKR1B1 (0.56) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL29375440 | 0.76 | MAPT (0.67) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL86392 | 0.76 | MAPT (0.67) | MAPTALDH1A1RAB9AAKR1B1MAPK14 | |
| SCHEMBL15766737 | 0.75 | MAPK14 (0.51) | AKR1B1MAPK14TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409406-B1 | ARYL-SUBSTITUTED AMINE DERIVATIVES USEFUL IN CANCER THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-08 | — | — | EP | disclosed |