Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563249 | 1.00 | PRMT5 (0.34) | PRMT5GRM5GRM7GRM3CHRM3 | |
| SCHEMBL9563351 | 1.00 | PRMT5 (0.34) | PRMT5GRM5GRM7GRM3CHRM3 | |
| SCHEMBL9563193 | 0.89 | GRM5 (0.42) | GRM5GRM7GRM3CHRM3ADRB3 | |
| SCHEMBL9563380 | 0.89 | GRM5 (0.42) | GRM5GRM7GRM3CHRM3ADRB3 | |
| SCHEMBL9563195 | 0.89 | GRM5 (0.42) | GRM5GRM7GRM3CHRM3ADRB3 | |
| SCHEMBL9563304 | 0.85 | BCHE (0.41) | CHRM3ADRB2ADRB3SLC6A2LMNA | |
| SCHEMBL9563283 | 0.84 | GRM5 (0.36) | GRM5GRM7GRM3CHRM3ADRB2 | |
| SCHEMBL9563278 | 0.84 | GRM5 (0.36) | GRM5GRM7GRM3CHRM3ADRB2 | |
| SCHEMBL9563313 | 0.84 | GRM5 (0.36) | GRM5GRM7GRM3CHRM3ADRB2 | |
| SCHEMBL9563231 | 0.84 | DRD4 (0.37) | PRMT5GRM5GRM7GRM3CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529365-A1 | Diarylmethoxypiperidine derivatives | Kaken Pharmaceutical Co., Ltd. (JP) | 1993-03-03 | — | — | EP | claimed |
| US-5190959-A | Antihistamines, antiallergens, treatment of ischemic heart disease | KAKEN PHARMACEUTICAL CO. LTD. (JP) | 1993-03-02 | — | — | US | claimed |
| EP-0529365-A1 | Diarylmethoxypiperidine derivatives | Kaken Pharmaceutical Co., Ltd. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5190959-A | Antihistamines, antiallergens, treatment of ischemic heart disease | KAKEN PHARMACEUTICAL CO. LTD. (JP) | 1993-03-02 | — | — | US | disclosed |