Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563252 | 0.93 | ALDH1A1 (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9563337 | 0.91 | KDM4E (0.57) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9563399 | 0.90 | KDM4E (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9563236 | 0.89 | BCHE (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL9563333 | 0.88 | CYP2D6 (0.60) | ALDH1A1KDM4EBCHEPARP14CYP2D6 | |
| SCHEMBL9563238 | 0.85 | CYP2D6 (0.65) | ALDH1A1KDM4ELMNABCHEPARP14 | |
| SCHEMBL9563349 | 0.84 | CYP2D6 (0.64) | ALDH1A1KDM4ELMNABCHEPARP14 | |
| SCHEMBL9563379 | 0.83 | CYP2D6 (0.55) | ALDH1A1KDM4EKMT2AMAPTBCHE | |
| SCHEMBL9563284 | 0.83 | CYP2D6 (0.55) | ALDH1A1KDM4ELMNABCHEPARP14 | |
| SCHEMBL9563223 | 0.83 | PARP14 (0.52) | LMNABCHEPARP14CYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529365-A1 | Diarylmethoxypiperidine derivatives | Kaken Pharmaceutical Co., Ltd. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5190959-A | Antihistamines, antiallergens, treatment of ischemic heart disease | KAKEN PHARMACEUTICAL CO. LTD. (JP) | 1993-03-02 | — | — | US | disclosed |