Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9563474 | 0.84 | LMNA (0.42) | ADORA2ALMNAFLT4KDREGFR | |
| SCHEMBL9563504 | 0.70 | ADORA2A (0.83) | ADORA2AADCY5 | |
| SCHEMBL8832570 | 0.67 | ADORA2A (0.46) | ADORA2ALMNA | |
| SCHEMBL28929098 | 0.67 | HPGD (0.54) | ADORA2AFLT4KDREGFRNPC1 | |
| SCHEMBL20149800 | 0.67 | LMNA (0.61) | ADORA2ALMNA | |
| SCHEMBL13208057 | 0.65 | LMNA (0.59) | ADORA2ALMNACYP1A2 | |
| SCHEMBL7140384 | 0.65 | LMNA (0.59) | ADORA2ALMNACYP1A2 | |
| SCHEMBL23283443 | 0.64 | SLC22A12 (0.44) | LMNARAB9AFGFR1FGFR4 | |
| SCHEMBL29971311 | 0.64 | SLC22A12 (0.44) | LMNARAB9AFGFR1FGFR4 | |
| SCHEMBL28929095 | 0.64 | CYP1A2 (0.54) | ADORA2AFLT4KDREGFRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532423-A1 | Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531597-A1 | Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |