SCHEMBL9564334

SCHEMBL9564334

CCC(=O)c1ccc2c(c1)CCC(C)N2C(C)=O

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.51
HPGD P15428 2/20 0.51
PDK1 Q15118 10/20 0.49
PDK2 Q15119 10/20 0.49
PDK3 Q15120 10/20 0.49
PDK4 Q16654 10/20 0.49
HTT P42858 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
MAPK1 P28482 1/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
TSHR P16473 3/20 0.46
LMNA P02545 1/20 0.46
KDM4E B2RXH2 1/20 0.45
RECQL P46063 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9243805 0.90 GAA (0.44) ALDH1A1HPGDPDK1PDK2PDK3
SCHEMBL26071929 0.79 ALDH1A1 (0.45) ALDH1A1HPGDPDK1PDK2PDK3
SCHEMBL26071772 0.79 ALDH1A1 (0.45) ALDH1A1HPGDPDK1PDK2PDK3
SCHEMBL16590074 0.79 NOTUM (0.59) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL26079007 0.79 NOTUM (0.59) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL26071914 0.79 CYP11B1 (0.47) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL14756207 0.78 PDK1 (0.54) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL26071793 0.78 PDK1 (0.54) ALDH1A1PDK1PDK2PDK3PDK4
SCHEMBL5780390 0.78 ALDH1A1 (0.70) ALDH1A1HPGDHTTNPC1RAB9A
SCHEMBL17018033 0.78 PDK1 (0.64) ALDH1A1PDK1PDK2PDK3PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555183-A1 Pesticides CIBA-GEIGY AG (CH) 1993-08-11 EP disclosed