SCHEMBL9564659

SCHEMBL9564659

O=C1NC(=O)C(Cc2ccc(OCCc3ccc4ccccc4c3)cc2)S1

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 11/20 0.62
PPARG P37231 11/20 0.62
PPARA Q07869 2/20 0.57
CYP3A4 P08684 1/20 0.57
RXRA P19793 1/20 0.57
HRH3 Q9Y5N1 1/20 0.55
MPC2 O95563 1/20 0.53
CYP2C8 P10632 1/20 0.53
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12515224 0.88 FFAR1 (0.69) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL13846702 0.86 PPARG (0.59) FFAR1PPARGPPARAMPC2CYP2C8
SCHEMBL19217845 0.84 FFAR1 (0.61) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL19217676 0.84 FFAR1 (0.61) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL6930674 0.84 FFAR1 (0.61) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL1072226 0.83 FFAR1 (0.77) FFAR1PPARGPPARACYP3A4HRH3
SCHEMBL9311827 0.83 PPARG (0.64) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL1016492 0.83 PPARG (0.57) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL9312385 0.83 PPARG (0.59) FFAR1PPARGPPARACYP3A4RXRA
SCHEMBL6931105 0.83 PPARG (0.70) FFAR1PPARGPPARACYP3A4RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0528734-A1 Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1993-02-24 EP disclosed