SCHEMBL1016492

SCHEMBL1016492

O=C1NC(=O)C(Cc2ccc(OCCc3cc4ccccc4[nH]3)cc2)S1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARG P37231 12/20 0.57
FFAR1 O14842 9/20 0.57
PPARA Q07869 2/20 0.53
CYP3A4 P08684 1/20 0.53
RXRA P19793 1/20 0.53
HRH3 Q9Y5N1 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4857396 0.87 PPARG (0.56) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL9564659 0.83 FFAR1 (0.62) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL8932685 0.81 HDAC8 (0.53) PPARGFFAR1PPARA
SCHEMBL12515224 0.81 FFAR1 (0.69) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL1072226 0.79 FFAR1 (0.77) PPARGFFAR1PPARACYP3A4HRH3
SCHEMBL9312385 0.78 PPARG (0.59) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL19559777 0.78 FFAR1 (0.61) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL9570670 0.77 FFAR1 (0.71) PPARGFFAR1PPARACYP3A4RXRA
SCHEMBL7837262 0.77 PPARG (0.50) PPARGFFAR1PPARA
SCHEMBL9311827 0.77 PPARG (0.64) PPARGFFAR1PPARACYP3A4RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1942898-B1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL (JP) 2011-11-09 EP claimed
EP-2001461-A2 COMBINATION TREATMENT OF METABOLIC DISORDERS Wellstat Therapeutics Corporation (US) 2008-12-17 EP claimed
EP-1942898-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES Takeda Pharmaceutical Company Limited (JP) 2008-07-16 EP claimed
EP-1931350-A2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2008-06-18 EP claimed
WO-2007117791-A2 COMBINATION TREATMENT OF METABOLIC DISORDERS WELLSTAT THERAPEUTICS CORPORATION (US) 2007-10-18 WO claimed
WO-2007033265-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2007033266-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2007033350-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2006034435-A2 METHODS AND COMPOSITIONS FOR TREATING GLUCOSE-ASSOCIATED CONDITIONS, METABOLIC SYNDROME, DYSLIPIDEMIAS AND OTHER CONDITIONS POINT THERAPEUTICS, INC. (US) 2006-03-30 WO claimed
WO-2016100301-A1 USE OF CADHERIN-11 ANTAGONISTS TO TREAT OBESITY-ASSOCIATED CONDITIONS AND OTHER METABOLIC DISORDERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2016-06-23 WO disclosed
WO-2015134752-A1 COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY CASE WESTERN RESERVE UNIVERSITY (US) 2015-09-11 WO disclosed
EP-2531501-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2012-12-12 EP disclosed
WO-2011097079-A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-08-11 WO disclosed
EP-2346498-A1 METHODS OF REDUCING SMALL, DENSE LDL PARTICLES Metabolex Inc. (US) 2011-07-27 EP disclosed
WO-2007033265-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO disclosed
WO-2007033266-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO disclosed
WO-2007033350-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO disclosed
WO-2006034435-A2 METHODS AND COMPOSITIONS FOR TREATING GLUCOSE-ASSOCIATED CONDITIONS, METABOLIC SYNDROME, DYSLIPIDEMIAS AND OTHER CONDITIONS POINT THERAPEUTICS, INC. (US) 2006-03-30 WO disclosed
EP-1483232-A1 SALTS OF NATEGLINIDE Novartis AG (CH) 2004-12-08 EP disclosed
WO-2003076393-A1 SALTS OF NATEGLINIDE NOVARTIS AG (CH) 2003-09-18 WO disclosed