Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27238087 | 0.86 | GRM5 (0.41) | NOTUMTTRALBMEN1KMT2A | |
| SCHEMBL1425100 | 0.86 | GRM5 (0.38) | NOTUMTTRALBMEN1KMT2A | |
| SCHEMBL3094691 | 0.81 | ALOX15 (0.38) | NOTUMHSD11B1CA2CA1GPR35 | |
| SCHEMBL7215604 | 0.76 | CYP2A6 (0.43) | TTRALBMEN1KMT2AHSD11B1 | |
| SCHEMBL481078 | 0.74 | NOTUM (0.43) | NOTUMCA2CA9CA1EGLN2 | |
| SCHEMBL29478779 | 0.74 | NOTUM (0.43) | NOTUMCA2CA9CA1EGLN2 | |
| SCHEMBL3082201 | 0.74 | CYP1A2 (0.44) | MEN1KMT2ACA2CA9CA1 | |
| SCHEMBL7219012 | 0.73 | CTSK (0.51) | — | |
| SCHEMBL9023790 | 0.71 | CCR1 (0.42) | NOTUMJAK2CCR1 | |
| SCHEMBL2160632 | 0.70 | GRM5 (0.42) | TTRALBMEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533131-A1 | Process for selectively mono-ortho-hydroxy alkylation of 4-substituted pyridine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |