Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GGT1 | P19440 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265728 | 0.77 | LMNA (0.44) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL24786817 | 0.72 | LMNA (0.42) | LMNAMAPTALDH1A1GAAPOLB | |
| SCHEMBL6543758 | 0.69 | ACHE (0.36) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL6544961 | 0.69 | LMNA (0.35) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL745834 | 0.68 | — | — | |
| SCHEMBL4264850 | 0.67 | CTDSP1 (0.39) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL1247747 | 0.65 | MAPK1 (0.42) | MAPTALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL9479712 | 0.65 | LMNA (0.44) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL2518688 | 0.64 | KDM4E (0.46) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL10772449 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525768-A1 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1993-02-03 | — | — | EP | disclosed |