Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435148 | 0.77 | PDGFRB (0.49) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL7430163 | 0.77 | CYP11B1 (0.47) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL9565318 | 0.77 | PDGFRB (0.48) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL9565316 | 0.75 | CYP2A6 (0.43) | MAPK1VCPCYP19A1CYP3A4CYP2A6 | |
| SCHEMBL9565370 | 0.74 | PDGFRB (0.46) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL9565358 | 0.72 | MAPK1 (0.41) | MAPK1VCPCYP3A4CYP2A6PDE5A | |
| SCHEMBL7434051 | 0.70 | PDGFRB (0.52) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL23124200 | 0.69 | MAPK1 (0.45) | PDGFRBMAPK1PARP10PARP11METAP2 | |
| SCHEMBL7495544 | 0.68 | PDGFRB (0.48) | PDGFRBAURKATTKAURKBINCENP | |
| SCHEMBL1435835 | 0.67 | CYP2A6 (0.54) | PDGFRBMAPK1PARP10PARP11METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543245-A1 | Renin inhibiting amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-26 | — | — | EP | disclosed |