SCHEMBL9565370

SCHEMBL9565370

CSCCCc1nc(-c2cccnc2)c[nH]c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.46
AURKA O14965 1/20 0.42
TTK P33981 1/20 0.42
AURKB Q96GD4 1/20 0.42
INCENP Q9NQS7 1/20 0.42
CYP2A6 P11509 4/20 0.40
CYP2E1 P05181 3/20 0.39
CYP3A4 P08684 3/20 0.39
CYP2C9 P11712 3/20 0.39
CYP2B6 P20813 3/20 0.39
CYP2C19 P33261 3/20 0.39
CYP2D6 P10635 2/20 0.39
MAPK1 P28482 2/20 0.38
ALDH1A1 P00352 1/20 0.37
DAO P14920 1/20 0.37
PIM1 P11309 1/20 0.36
PIM3 Q86V86 1/20 0.36
PIM2 Q9P1W9 1/20 0.36
ALK Q9UM73 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7435148 0.78 PDGFRB (0.49) PDGFRBAURKATTKAURKBINCENP
SCHEMBL9565336 0.76 CYP2A6 (0.41) CYP2A6CYP2E1CYP3A4CYP2C9CYP2B6
SCHEMBL7430163 0.75 CYP11B1 (0.47) PDGFRBAURKATTKAURKBINCENP
SCHEMBL9565313 0.74 PDGFRB (0.46) PDGFRBAURKATTKAURKBINCENP
SCHEMBL9565345 0.73 MAPK1 (0.40) CYP2A6CYP2E1CYP3A4CYP2C9CYP2B6
SCHEMBL19323015 0.71 CYP2A6 (0.46) PDGFRBCYP2A6CYP2E1CYP3A4CYP2C9
SCHEMBL7434051 0.70 PDGFRB (0.52) PDGFRBAURKATTKAURKBINCENP
SCHEMBL1133233 0.69 CYP2A6 (0.47) PDGFRBAURKATTKAURKBINCENP
SCHEMBL455756 0.69 MAPK1 (0.42) PDGFRBAURKATTKAURKBINCENP
SCHEMBL7495544 0.69 PDGFRB (0.48) PDGFRBAURKATTKAURKBINCENP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543245-A1 Renin inhibiting amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1993-05-26 EP disclosed