SCHEMBL9565345

SCHEMBL9565345

CSCCCc1nc(-c2cccnc2)cnc1NN

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.40
CYP2A6 P11509 6/20 0.39
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
PTK2 Q05397 1/20 0.38
ATR Q13535 9/20 0.37
CYP3A4 P08684 4/20 0.37
CYP2E1 P05181 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2B6 P20813 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2D6 P10635 1/20 0.37
LOXL2 Q9Y4K0 1/20 0.36
TLR8 Q9NR97 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7333646 0.85 MAPK1 (0.43) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL9565336 0.81 CYP2A6 (0.41) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL7430157 0.79 MAPK1 (0.42) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL7437851 0.77 CYP11B1 (0.45) MAPK1CYP2A6ATRCYP3A4CYP2E1
SCHEMBL9565358 0.76 MAPK1 (0.41) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL9565370 0.73 PDGFRB (0.46) MAPK1CYP2A6CYP3A4CYP2E1CYP2C9
SCHEMBL7434057 0.72 MAPK1 (0.45) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL7430001 0.71 MAPK1 (0.41) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL9315752 0.71 MAPK1 (0.41) MAPK1CYP2A6HSP90AA1HSP90AB1PTK2
SCHEMBL7432125 0.70 MAPK1 (0.40) MAPK1ATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543245-A1 Renin inhibiting amino acid derivatives F. HOFFMANN-LA ROCHE AG (CH) 1993-05-26 EP disclosed