Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565496 | 1.00 | LMNA (0.42) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565500 | 1.00 | LMNA (0.42) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL599239 | 0.72 | TSHR (0.47) | LMNATSHRTACR1MMP2MMP3 | |
| SCHEMBL9565499 | 0.71 | TSHR (0.39) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565495 | 0.71 | TSHR (0.39) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565501 | 0.71 | TSHR (0.39) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565550 | 0.71 | TSHR (0.39) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565492 | 0.71 | TSHR (0.39) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565517 | 0.69 | TAAR1 (0.37) | LMNATSHRTACR1BCHEACHE | |
| SCHEMBL9565519 | 0.69 | TAAR1 (0.37) | LMNATSHRTACR1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554025-A2 | Fluorinated cyclobutyl purines and pyrimidines | E.R. SQUIBB & SONS, INC. (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1991018969-A1 | FLUORINATED BIS(HYDROXYMETHYL)CYCLOBUTYL PURINES AND PYRIMIDINES | E.R. SQUIBB & SONS, INC. (US) | 1991-12-12 | — | — | WO | disclosed |